Unravelling shared disease mechanisms of ADHD and obesity by large-scale multidimensional data analyses

Ditte Demontis –Professor, Department of Biomedicine, Aarhus Universitet
Grant amount: DKK 11,797,535

As stated by the researchers: “Attention deficit hyperactivity disorder (ADHD) is a childhood psychiatric disorder which affects around 5% of children and 2.5% of adults and is associated with increased risk of obesity. Here we aim to identify biological disease mechanisms shared across ADHD and obesity, and impulsive behaviors contributing to obesity in the general population.

We will perform large-scale genetic cross-disorder analyses and link identified shared genetic risk variants to genes, affected tissues and cell types and cell states by comprehensive integrative analyses of genomics and functional genomics data. Additionally, we will predict obesity in ADHD and the general population using biologically informed machine learning approaches.

The project will deliver ground-breaking knowledge about ADHD-obesity biology and has the potential to impact clinical management by allowing for stratification of ADHD patients to identify those at high risk for obesity.”

Project participants
Ditte Demontis
Professor, Department of Biomedicine, Aarhus Universitet

Simon Rasmussen
Associate Professor, Department Novo Nordisk Foundation Center for Protein Research, Københavns Universitet