Islet Cartography – Multi-layered mapping of islets of Langerhans in health and disease
This project will shed new light on the regulatory and functional architecture of the human pancreatic Islets of Langerhans with the aim of furthering the understanding of how it contributes to health and disease, most notably to diabetes.
In recent years, hundreds of human islet samples have been analysed with new high-throughput technologies, providing insight into single cell transcriptomes, spatial organisation, chromatin accessibility, etc. This project aims to collect, integrate, and jointly analyse these data sets with new data science methods to build a comprehensive map of the human islet.
The resulting web resource will be made publicly available for other researchers to pave the way for new insight that could lead to prevention, diagnosis and treatment of diabetes and other pancreas-related diseases.