Charting territories: Refining case-cohort estimation and utilize register-based factors in genetic analyses

Liselotte V. Petersen says: “The overarching purpose is to optimize estimation in case-cohort samples and explore genetic pathways using information from Danish registers. The case-cohort sampling design has several advantages compared to other sampling designs as the control group can be reused to study other case groups and absolute measures such as percentages (and the certainty of the percentage) can be estimated. However, this is not covered in standard statistical packages for scenarios such as competing risk. Therefore, we will explore the possibilities and provide recommendations to optimize estimations in case-cohort studies, including time to event data in genome-wide association studies. We also aim to find subgroups of cases that have distinct biological pathways to disease by utilizing register-based information on exposures in various case-only genome-wide association studies.”